Job Description

The Computational Biology Genomics Laboratory (CBGL) has an open position for a Senior Scientist. This position will provide the selected candidate with the opportunity to contribute to projects of scientific and institutional importance. The CBGL is a central laboratory supporting principal investigators in the Department of Computational Biology, their collaborators, and multi-institutional partnerships initiated by St. Jude Children’s Research Hospital. Current collaborations include the Transcription Collaborative, St. Jude Life, and the Childhood Cancer Survivorship Study.

The CBGL supports several areas of faculty research and interest. Including studies on genomic variation in cancer, the development of improved tools for the analysis and detection of pediatric cancer, cell programs in the tumor micro-environment, and the characterization of the properties of single cells during development and in tumor evolution.

A portion of the laboratory is currently supporting the St. Jude Life study with the Department of Epidemiology and Cancer Control. Investigations are being conducted at the bulk and single cell level to better understand the molecular underpinnings impacting the quality of life of survivors, such as frailty, and the risk of secondary cancers from cancer treatment during childhood.

The selected candidate will utilize their demonstrated experience and problem-solving skills across a broad range of experimental techniques including but not limited to assays in molecular biology, genomics, advanced imaging methods, and tissue processing to generate and analyze high quality data in collaboration with faculty and scientists in the department of computational biology.

Job Responsibilities:

• Coordinate team-based, multi-disciplinary projects independently under overall direction of the PI.
• Build deep understanding of the field and be familiar with current literature in the field and related disciplines.
• Develop new research protocols, techniques, and procedures.
• Identify, process, organize, interpret, review, and report relevant experimental data.
• Monitor data collection and entry methods to meet quality standards.
• Present research to colleagues within and outside the institution; publish as co-author and/or independently draft sections of research manuscripts.
• Guide/make recommendations for optimal lab operations, administration, and training.
• Regularly trains and oversees the work of others in laboratory techniques and procedures.
• Performs other related duties as assigned in order to meet the goals of the department and institution.
• Maintains regular and predictable attendance.

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required

Minimum Experience:

• Ten (10) years relevant work experience is required
• Eight (8) years of relevant work experience is required with a master's degree
• Five (5) years of relevant work experience is required with a PhD

Special Skills, Knowledge, and Abilities:

• Ideal candidates should have hands-on experience with various single cell RNA sequencing methods (droplet-based methods and combinatorial Indexing) and single cell whole genome amplification methods (MDA, PTA).
• Preferably experienced in generating data using spatial transcriptomics platforms such as the Visium and Xenium.
• Ability to train colleagues in new methods.
• Exposure to Immunohistochemistry and Immunofluorescence microscopy.
• Familiarity with cell sorting and cell staining methods.
• Basic understating of command line tools and experience running commercial pipelines such as Cell Ranger and Space Ranger using both cloud applications and computational clusters.
• The ability to identify and implement new methods or protocols related to single cell genomics from literature or commercial vendors.
• Understanding and experience with next-generation sequencing platforms and workflows.
• Perform lab related duties as assigned to meet the goals of the department.
• Hands-on experience in cell biology techniques such as cell culture, in-vitro cell assays, viral transduction, and tissue sample handling.

Strongly Preferred Experience:

• Experience working with applicable regulations and lab protocols preferred.
• Experience working with computerized databases and/or software preferred as applicable.
• Experience in lab and scientific project coordination, maintenance, and other research support activities preferred.

About St. Jude:

St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300-faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work,” and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture.

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist - Computational Biology Genomics Laboratory (CBGL).

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